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Roger Brent : ウィキペディア英語版
Roger Brent

Roger Brent (born December 28, 1955) is an American biologist known for his work on gene regulation and systems biology. He studies the quantitative behaviors of cell signaling systems and the origins and consequences of variation in them. He is a researcher at Fred Hutchinson Cancer Research Center and a Fellow of the American Association for the Advancement of Science.
==Early life==
Brent grew up in Hattiesburg, Mississippi and received his BA in Computer Science and Statistics from the University of Southern Mississippi, where he applied AI techniques to protein folding. He performed PhD (1982)〔"Regulation of the cellular response to DNA damage" (1982)〕 and postdoctoral work (1985) in Biochemistry and Molecular Biology at Harvard University in the laboratory of Mark Ptashne. In work there he cloned the E. coli LexA repressor and showed how it controlled the cell's response to DNA damage, used LexA as a repressor in yeast, and created fusion proteins that used LexA to bring portions of yeast Gal4 and other transcription regulatory proteins to synthetic reporter genes in yeast. These domain swap experiments established the domain structure of eukaryotic transcription regulatory proteins.

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